As an example, Fig 8A shows the SGA-FIs and their target cancer processes for a tumor (TCGA-B1-A657) of Kidney Renal Papillary cell carcinoma (KIRP), where genes in 9 oncogenic hallmark process from MSigDB are significantly enriched among the DEGs, including the following pathways that are strongly regulated by one of more SGA-FIs: the Epithelial Mesenchymal Transition pathway, the KRAS signaling pathway, the TNFA signaling via NFKB pathway, and the IL2 STAT5 signaling. The gene discussed is TNF; the disease is cancer.