KEAP1 and cancer: The top 15 SGA-FIs connected with CSMD3 and ZFHX4 (Fig 7D and Fig 7E) also form densely connected networks that include well-known cancer drivers, such as KRAS, GATA3, KEAP1, ERBB2 and STK11, suggesting that alteration of CSMD3 and ZFHX4 may perturb some of the same signaling pathways as do these known drivers.