Interestingly, we also found that TTN was perturbed in one cell line (VCAP), and 5 out of 7 predicted target DEGs responded to manipulation of TTN. Among them, 4 genes (SPP1, STAT1, C5 and GPER1) are known to be associated with development and/or progression of cancer [54–57]. Here, GPER1 is linked to cancer.