Thus, tumors with an aberrant PI3K/AKT pathway usually host an SGA in one of these members, although they likely share target genes, e.g., the DEG MPL. A causal discovery algorithm should attribute an MPL DEG event in a tumor to a member SGA of the PI3K/AKT pathway with high probability if one of those SGAs appears in the tumor. Here, AKT1 is linked to neoplasm.