3-β-hydroxysteroid dehydrogenase (HSD3B2) expression in control GLCs was 400 times in higher than in control GLCs (< 0.0001) and was 300 times higher in PCOS GLCs than in PCO GCs (P < 0.001) (Fig. 4C). This evidence concerns the gene HSD3B2 and polycystic ovary syndrome.