Jakimiuk et al. (15) also studied GCs from women with PCOS and found increased gene expression of LHCGR and CYP11A1 (catalyzing conversion of cholesterol to pregnenolone by side-chain cleavage) in GCs from hSAFs compared with cells from regularly cycling women. The gene discussed is CYP11A1; the disease is polycystic ovary syndrome.