PIGR, an epithelial glycoprotein that interacts with secretory IgA, is critical for regulating the secretory IgA level by transporting locally produced IgA.15 Because secretory IgA plays an important role in protecting mucosal surfaces such as the ocular surface against pathogens and antigens,15 the downregulated expression of the PIGR transcript in the conjunctival epithelium of patients with SJS with SOC may compromise immune protection of the ocular surface. Here, PIGR is linked to Schwartz-Jampel syndrome.