The teneurin function appears to be required for a fundamentally important signalling mechanism conserved in invertebrates and vertebrates; it impacts many processes that rely on cell-cell contact throughout development.17 Although the clinical importance of teneurin-2 on the ocular surface remains unclear, we found that teneurin-2 protein is expressed in human conjunctival epithelium and that it may be upregulated in the conjunctival epithelium of patients with SJS. Here, TENM2 is linked to Schwartz-Jampel syndrome.