Few studies evaluate the modulation of the transcriptional factor Nrf2 during parasitic diseases, such as Trypanosoma cruzi infection in mice, where NRF2/HO-1 pathway was induced with cobalt protoporphyrin, which reduced parasitemia and tissue parasitism, while an inhibitor of HO-1 activity increased T. cruzi parasitemia [39]. This evidence concerns the gene HMOX1 and parasitic infectious disease.