CD274 and colorectal cancer: Moreover, univariate survival analysis has showed that positive expression of PD-L1 was inversely correlated with OS (p=0.002) and multivariate survival analysis has further confirmed that positive status of PD-L1 is an independent factor for poor prognosis of patients (HR=1.914, 95% CI:1.031-3.553, p=0.040), indicating that PD-L1 might play an important role in the generation and development of colorectal cancer.