ADORA2A and colorectal neoplasm: Therefore, the aim of this study was to evaluate the expressions of PD-L1 and A2aR proteins in human colorectal tumor tissues and adjacent nontumor tissues by using immunohistochemistry (IHC), and to further investigate whether PD-L1 and A2aR expressions are associated with the clinicopathological features and prognosis of patients, thereby finding potential prognostic indicators and treatment strategies for this disease.