PLOD1 and ovarian carcinoma: Although LH has demonstrated potent activities of growth inhibition against ovarian cancer cells (IC50 = 1.2 μM) [12], the inhibitory effects against Chang's liver cells and HUVEC cells were weak, with IC50 higher than 256 μM. These results confirmed the selectivity of LH, and so was the safety, which could also be seen in mice and dogs receiving daily injection: LH did not cause obvious effects, such as loss of body weight [12, 13].