One of the most frequent translocations observed in AML is t(9;11) and the Myb gene is up-regulated in cells from these patients (Lee et al., 2006) and over-expression of Myb contributes to leukemogenesis in human AML (K562)-SCID chimeric mice (Ratajczak et al., 1992). This evidence concerns the gene MYB and acute myeloid leukemia.