PTEN and colorectal carcinoma: Although the exact contribution of Exos in the modulation of PTEN was not explored in this work, Yang et al. found that Exos released by cetuximab-resistant CRC cells expressed high levels of UCA1-lncRNA and demonstrated that exosomal delivery of UCA1 to cetuximab-sensitive cells induced resistance to anti-EGFR agents (62).