WWOX and B-cell non-Hodgkin lymphoma: We have previously observed that hypomorphic Wwox mice developed B cell lymphomas at old age (11) and this appears in agreement with observations indicating that heterozygous mice with only a functional Wwox allele (i.e., Wwox+/−) develop an increased B cell lymphoma incidence when exposed to the carcinogen ethyl-nitrosourea (8).