To explore the role of TICRR in affecting tumor growth in vivo, we injected shTICRR- and shControl-HCC1806 cells into BALB/c nude mice and found that the growth of xenograft tumors was strikingly slower in mice injected with shTICRR-HCC1806 cells (tumor volume on the last day: control = 538.4 ± 49.68 mm3, TICRR-depletion = 119.4 ± 14.56 mm3, p = 2.12 × 10−6) (Figures 3A,B). The gene discussed is TICRR; the disease is neoplasm.