PRRT2 and acute myeloid leukemia: Midostaurin, a multi-kinase inhibitor that was originally developed as a protein kinase C (PKC) inhibitor for treatment of patients with solid malignancy (10), has already been approved by the FDA for treatment of acute myelocytic leukemia (AML) with Fms-like tyrosine kinase 3 (FLT3)-mutant subtype (11).