FLT3 and acute myeloid leukemia: More recently, a global study of the efficacy and safety of midostaurin plus chemotherapy in newly diagnosed patients with FLT3 mutation negative (FLT3-MN) acute myeloid leukemia (AML) is recruiting (NCT03512197), and a phase II clinical evaluation is recruiting for midostaurin associated with standard chemotherapy in patients with core-binding factor leukemia (AML FLT3) (NCT03686345).