ABCB1 and cancer: As shown in Figure 2, midostaurin significantly sensitized ABCB1-overexpressing cancer cells KB-C2 (Figures 2A–C) and SW620/Ad300 (Figures 2E–G) to ABCB1 substrates (doxorubicin, paclitaxel, and colchicine), compared with their control resistance cells, and this sensitization occurred in a dose-dependent manner.