TP53 and non-small cell lung carcinoma: One of the largest studies analyzing the frequency of p53 mutations showed that in colorectal cancer, 50% of patients with p53 mutation had one or more pathogenic gene mutations; 47% with non-small cell lung cancer (NSCLC) had one or more pathogenic gene mutations, and 52% of glioma patients had at least one or more pathogenic gene mutations [11].