IGHE and asthma: Major Criteria: (1) asthma, (2) presence of fleeting or fixed pulmonary opacities on chest radiograph, (3) immediate cutaneous hypersensitivity reaction to Af, (4) total serum IgE elevated, more than 1000 IU/mL, (5) precipitating antibodies against Af, (6) peripheral blood eosinophilia, (7) central or proximal bronchiectasis with normal tapering of distal bronchi