Some of the features may be present only during the acute (stage 1) or the exacerbation (stage 3) stages [3]. The major criteria consisted of patients diagnosed with asthma, the presence of pulmonary opacities on chest radiographs, immediate cutaneous reactivity to Af, the serum IgE being more than 1000 IU/mL, precipitating antibodies against Af, peripheral blood eosinophilia, and central or peripheral bronchiectasis with normal tapering of distal bronchi [15-16]. This evidence concerns the gene IGHE and Increased total eosinophil count.