The minimum criteria consists of patients with asthma or cystic fibrosis, worsening lung function, a positive skin prick test with Aspergillus species, a total serum IgE greater than 1000 ng/mL (416 IU/mL), increased Aspergillus species-specific IgE and IgG antibodies, and finally, infiltrates noted on the chest radiograph [4]. The gene discussed is IGHE; the disease is cystic fibrosis.