Indeed, the relationship between PRL and SLE and the underlying mechanisms remain controversial; however, the general perception is that PRL does play a pathogenic role in SLE, particularly with respect to hyper-prolactinemia (Costanza et al., 2015; Karimifar et al., 2013; Shelly, Boaz & Orbach, 2012). This evidence concerns the gene PRL and systemic lupus erythematosus.