Enhanced expression of type 1 IFN-inducible genes has been detected in SLE, and this so-called “IFN signature” has been shown to play a critical role in the pathogenesis of SLE and is associated with active disease (Baccala et al., 2007; Baechler et al., 2003; Li et al., 2010; Ronnblom & Eloranta, 2013). The gene discussed is IFNA1; the disease is systemic lupus erythematosus.