The GSEA of GSE98793 gene expression profiles suggested that MDD is mainly related to the apoptosis pathway, and the tumor necrosis factor (TNF), Toll-like receptor (Fig. 4A), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathways (Fig. 4B). Here, NFKB1 is linked to major depressive disorder.