PSME4 and diabetes mellitus: Module subnetwork 1, where red nodes represent the common genes, green nodes represent T2DM genes and blue nodes are DEGs associated with peri-implantitis, showed PSMD10 and PSMD6 as cross-talk genes, which directly interacted with one gene closely related to diabetes (LTA), as well as with DEGs in peri-implantitis (PSM family genes (PSMC2, PSMA4, PSME4, etc.), SKP2, EIF3F, USP14, UBLCP1, etc.)(Fig. 3).