In peri-implantitis, NFKB1 has been previously identified as a key candidate gene (Zhang et al., 2017) and is shown to regulate inflammation-induced osteoclastogenesis by regulating receptor activator of NF-κB ligand (RANKL)—mediated osteoclast formation and activation in peri-implantitis (Boyce et al., 2015). Here, TNFSF11 is linked to Peri-Implantitis.