From the three main lists nominated for candidate driver gene status from the three pathways, derived using the heatmap and the GS, 20 were known driver genes that included well annotated driver genes like KRAS NRAS, HRAS, FOXO1, and FOXO3. A literature search revealed each of the remaining genes has been implicated in the development of cancer in at least one study. Here, FOXO3 is linked to cancer.