ACE and acute kidney injury: However, given that there are plausible mechanisms linking SGLT-2 inhibitors to AKI, especially when having concomitant use of ACE inhibitors, ARBs, diuretics, or other nephrotoxic medications such as nonsteroidal anti-inflammatory drugs, amphotericin, and radiocontrast media [9], it is important to consider this adverse effect when prescribing SGLT-2 inhibitors.