Next, we investigated to what extent the score categories for the three different prostate cancer expressed PDE4D transcripts were determined to be mutually exclusive in individual patient samples or, whether, the same score category (e.g., [1, 2] or [4, 5]) was seen across the same samples for the three long form PDE4D splice variants we analysed here. This evidence concerns the gene PDE4D and Familial prostate cancer.