Later, Tamaki et al. reached a similar result in the Japanese population; they found that the genotype frequency of Gly460Trp polymorphism and plasma renin activity were significantly different in the normotensive, borderline, and hypertensive groups and that the 460Trp allele might be associated with hypertension, especially the low renin-type hypertension [52], which to some extent supported the result of Cusi's study. Here, REN is linked to Hypertension.