IL2 and myocardial infarction: Additionally, several recent studies have suggested that Tregs may antagonize myocardial remodeling and improve the mechanical function of the MIRI heart via epicardial Hippo signaling (epicardial YAP/TAZ can recruit Tregs to injured myocardium after MI) [93], paracrine effects [93, 94], and interactions with the IL-2/Anti-IL-2 complex [95].