Among these genes, SPARCL1 was identified as a tumor suppressor gene.37 ZCCHC24 is strongly correlated with sensitivity to drug treatment.38 MFAP4 is downregulated in several types of cancer and it was recently suggested to be a marker for developing therapies against cancer.39 These results suggest that the high expression of the genes that are strictly dependent on ZEB1 pathway may play protective roles in cancer progression, or they can be served as markers for improved prognosis. The gene discussed is MFAP4; the disease is cancer.