In a previous study, Lactobacillus was reported to be negatively correlated with IGT and T2DM, while Desulfovibrionaceae was positively correlated with these factors [46, 47]. Lactobacillus enhances insulin secretion in T2DM and modifies the structure of polysaccharides to regulate the gut microbiota [48, 49]. The gene discussed is INS; the disease is type 2 diabetes mellitus.