SMAD3 and myalgic encephalomeyelitis/chronic fatigue syndrome: In addition, we found that attenuation of SCE on fibrosis was associated with downregulation of TGF-β/Smad3 signaling and SCE reduced increased levels of H3K4me3 and H3k36me3 in the Smad3 promoter region induced by TGF-β in CFs.