CALR and neoplasm: We found that PKHB1-treatment induces the exposure and release of several DAMPs (calreticulin (CRT), HSP70, HSP90, ATP, and HMGB1) in human T-ALL cell lines (CEM, MOLT-4) and their murine counterpart (L5178Y-R cells) [23]. In vivo, prophylactic vaccination experiments with PKHB1-treated cells prevented tumor establishment in immunocompetent BALB/c mice [23].