During our investigations on acidity and melanoma progression we collected several findings suggesting that acidic melanoma cells could be a very good candidate for also expressing an anoikis resistance, such as a switch to an EMT profile (high N-Cadherin, low E-Cadherin), high MMP-dependent invasive ability, apoptotic resistance, and an AKT/mTOR privileged pathway [20, 23]. Here, CDH1 is linked to melanoma.