CDH2 and cancer: Indeed many recent studies show that EMT increases metastatic potential of cancer cells by mediating anoikis resistance [31, 32]; particularly it was demonstrated that the depletion of E-cadherin promotes mammary cell survival following loss of cell adhesion to the ECM [33], and N-cadherin expression protects melanoma cells from anoikis [34, 35] and confers apoptosis resistance to esophageal carcinoma cells [36].