As other markers of a possible anoikis resistant phenotype, we show (Figure 1(a)) upregulation in acidic melanoma cells of the epidermal growth factor receptor (EGFR), an additional prosurvival signaling mediator linked to ERK and AKT pathways, and of the Tyrosine kinase with immunoglobulin-like and EGF-like domains (Tie)-1, a new class of receptor tyrosine kinases specifically expressed during vascular endothelial cell growth and differentiation. The gene discussed is TIE1; the disease is melanoma.