Notably, SPNS2 (sphingolipid transporter 2) which most incited tumor metastasis by regulating lymphocyte trafficking [32], had higher expression levels in TP53-mutated BCs than in TP53-wildtype BCs in TCGA (Student's t test; FDR=1.34∗10−6; SPNS2 expression data was lacking in METABRIC). This evidence concerns the gene TP53 and neoplasm.