BSG and colorectal carcinoma: In particular, Y. B. Hu et al. have documented the ability of exosome Wnt derived from fibroblasts to induce chemoresistance in CRC, thus suggesting that the therapeutic response could be enhanced by interfering with Wnt signaling [19–21] Furthermore, Y. Tian et al. have proved the presence of a significantly elevated level of CD147-positive EVs in CRC patients compared to healthy controls, thus indicating this protein as promising marker for CRC diagnosis [22].