PTK7 and triple-negative breast carcinoma: However, recently Pfizer and Abbvie/Stemcentrx design, an ADC composed of a humanized anti-PTK7 and a cleavable auristatin microtubule inhibitor (Aur0101), showed capacity to target tumor-initiating cells (TICs) in triple-negative breast cancer (TNBC), ovarian cancer (OVCA), and non-small-cell lung cancer (NSCLC).