MEFV and familial Mediterranean fever: FMF is caused by mutations in the MEFV missense SNPs (we were focusing on SNPs which are located in the coding region because it is much important in disease causing potential, which are responsible for amino acid residue substitutions resulting in functional diversity of proteins in humans) [20] coding for pyrin, which is a component of inflammasome functioning in inflammatory response and production of interleukin-1β (IL-1β).