ETS1 and systemic lupus erythematosus: In summary, our data demonstrated that rs4937333 plays an important role in SLE susceptibility, modulating the epigenetic regulation of a critical SLE-related gene, ETS1, especially in B cells, rs4937333 impairs the binding of miR-5003-3p to ETS1 mRNA, which leads to enhanced differentiation of B cells into plasma cells.