An increasing number of 3′-UTR SNPs in miRNA-binding sites has been found to be associated with SLE, including rs1057233 in the miR-569-binding site of SPI1 (Hikami et al., 2011) and rs3853839 in the miR-3148-binding site of toll-like receptor 7 (TLR7) (Deng et al., 2013). The gene discussed is TLR7; the disease is systemic lupus erythematosus.