ChREBPadiposeKO mice have lower serum levels of PAHSAs, while PAHSA supplementation, in particular the 9-PAHSA isomer, rescues ChREBPadiposeKO global insulin resistance and adipose tissue inflammation, confirming that loss of adipose-ChREBP is sufficient to cause insulin resistance (Vijayakumar et al., 2017). This evidence concerns the gene MLXIPL and Insulin resistance.