Interestingly, specific co-recruitment of Phf2 and ChREBP to the promoter of nuclear factor erythroid 2 like 2 (Nrf2) contributes to the protective effect of Phf2 against increased reactive oxygen species (ROS) and NAFLD progression in the context of hyperglycemia (Bricambert et al., 2018). Here, PHF2 is linked to Hyperglycemia.