Inhibition of two key enzymes in glycolysis: hexokinase (HK) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by 2-deoxyglucose (2-DG) and sodium iodoacetate (IA), respectively, reduced MDSCs expansion, leading to a delay in tumor progression via induction of ROS-mediated apoptosis of MDSCs (40). Here, GAPDH is linked to neoplasm.