However, AIRE mRNA was strikingly induced, up to 191 ± 79 fold, by IL-1β in RA FLS (p = 0.001, n = 4) and 42 ± 4 fold (p = 0.0006, n = 3) in OA FLS (Figure 2A) after 24 h. Here, IL1B is linked to rheumatoid arthritis.