Western blot data showed that the protein levels of PCNA, CDK4, CDK6, Cyclin D1, MMP-2, MMP-9, and Bcl-2 were decreased, but cleaved caspase-3 was increased in tumor tissues of ApoE KO mice compared to those of WT mice (Supplementary Figure 2A). Here, CASP3 is linked to neoplasm.