LGALS13 and preeclampsia: Of importance, Gal-13 is secreted from the syncytiotrophoblast into the maternal circulation, and low Gal-13 concentration in the maternal circulation in the first trimester was found in women who subsequently developed preterm preeclampsia (115–122), a severe obstetrical syndrome with a strong systemic immune dysregulation (51, 82, 86, 123–128) that already exists in the first trimester (129).