Since we and our collaborators have shown that Gal-13 and Gal-14 induce the apoptosis of pre-activated T lymphocytes (53) and that Gal-13 increased IL-1α and IL-6 secretion from peripheral blood mononuclear cells (PBMCs) in pregnant women (114), an unanswered question remained: are Gal-13 and Gal-14 critical regulators of immune processes at the early maternal-fetal interface that can be considerably dysregulated in miscarriage? This evidence concerns the gene LGALS13 and spontaneous abortion.