To clarify the role of naturally occurring oligosaccharides featuring fucosyl- and sialyl-residues on the course of colitis, we have investigated the effects of the orally supplemented oligosaccharides 2-fucosyllactose (2FL), 3-fucosyllactose (3FL), 3-sialyllactose (3SL), and 6-sialyllactose (6SL) on the course of intestinal inflammation in interleukin-10 null (Il10-/-) mice after weaning. This evidence concerns the gene IL10 and colitis.