DPP4 and Hypoglycemia: To summarize the studies undertaken with DPP-4 inhibitors as monotherapy or in combination with other glucose-lowering therapies in the years around 2010, they showed that the inhibitors reduce HbA1c by ≈0.5–0.8% (5–8 mmol/mol), have a low risk for hypoglycemia (except in combination with sulfonylurea), and are weight neutral.