The major regulatory factors that bind in this region (TRIM28, SMARCA4) are associated with autism (89–91); therefore, inversions or other rearrangements of this region may impact on expression of F8A2/F8A3 region-associated transcription or on flanking genes (CLIC2, TMLHE, SPRY3), potentially contributing to autism risk. Here, SPRY3 is linked to autism.