Based on previous studies, miR-10a was reported to be involved in collagen type I generation of hypertrophic scars, embryonic cardiac development, type 2 diabetes mellitus and chronic myeloid leukemia CD34+ cells, etc. biological processes by regulating its targeting genes, such as Pai-1, Tbx5, Creb1, Usf2 (Agirre et al., 2008; Wang et al., 2014; Li et al., 2015; Shan et al., 2016). The gene discussed is CREB1; the disease is diabetes mellitus.