Significantly reduced eosinophils infiltration in BALF and airway hyperresponsiveness in OVA-sensitized mice. Potent attenuation of serum IgE level, TH2 cytokines (IL-4, IL-5 and IL-13) production and NF-κB activation with oral administration of 15, 30 and 60 mg/kg. The gene discussed is NFKB1; the disease is airway hyperresponsiveness.