Immunoglobulin E (IgE) is of central importance in the regulation of immune responses against parasitic infestations and most importantly, it is also recognized as a main mediator for immediate-type allergies or type I hypersensitivity reactions, such as allergic asthma, rhinitis, atopic diseases, anaphylaxis, etc. (Al-Mughales, 2016). The gene discussed is IGHE; the disease is allergic asthma.