IGHE and anaphylaxis: Serum histamine release was significantly reduced at 100 and 1,000 mg/kg, with 500 mg/kg as the effective dose that completely protected compound 48/80-induced mice from systemic anaphylaxis. At doses ranging from 1–1,000 mg/kg, a dose-dependent inhibition of PCA reaction was resulted in anti-DNP IgE-challenged mice.