These include positive effects related to Aβ or tau reduction (Li and Wang, 2018), increased number of neurons (Geng et al., 2018), inhibition of apoptosis (Zhang et al., 2017), protection of synapses (Lee et al., 2016), transformation of other cellular elements into missing/deficient neurons in AD (Ghasemi-Kasman et al., 2018), and so on. The gene discussed is MAPT; the disease is Alzheimer disease.