MAPT and Alzheimer disease: Also, co-incubation of Aβ peptide with LPS was shown to potentiate amyloids fibrillogenesis (Asti and Gioglio, 2014), and systemic injection of LPS in a transgenic AD mouse model resulted in severe amyloid deposition and tau pathology (Aziz et al., 2013; Mitew et al., 2013; Paula-Lima et al., 2013; Saulnier et al., 2013).