In addition, among patients with irritable bowel syndrome (IBS), the levels of proinflammatory cytokines including interleukin (IL)-6 and IL-8 were elevated as a result of adrenocorticotropic hormone (ACTH) stimulation (i.e., cortisol release; Dinan et al., 2006). The gene discussed is CXCL8; the disease is irritable bowel syndrome.