As one of the targets of miR-10b-5p (Jamwal and Kumar, 2015), BDNF down-regulation in HD brains might be mediated through up-regulation of miR-10b-5p, which has a binding target within the 3′-UTR of the BDNF transcript (Varendi et al., 2014). This evidence concerns the gene BDNF and Huntington disease.