Finally, neuronal autophagy upon brain ischemia seems to be a part of pro-survival signaling pathway, that involves PI3K/Akt/TSC2 /mTOR/P70S6K signaling pathway (Wang et al., 2012; Papadakis et al., 2013) and Akt/CREB pathway (Carloni et al., 2010). This evidence concerns the gene AKT1 and brain ischemia.