PLAT and Stroke: However, both treatments have their own limits: tPA has a narrow therapeutic window (4.5 h after stroke onset) (Hacke et al., 2008), presents a risk of hemorrhagic transformation and has a low recanalisation rate (National Institute of Neurological Disorders and Stroke rt-Pa Stroke Study Group, 1995; Thiebaut et al., 2018); while endovascular thrombectomy is restricted to large vessel occlusions (Berkhemer et al., 2015).