Beclin-1 seems central, as caveolin1, an integral membrane protein, is able to activate autophagy through its binding to Beclin-1/VPS34 complex: in Caveolin1 knock out mice, autophagy is impaired, leading to greater tMCAo-induced cerebral infarct (Nah et al., 2017). This evidence concerns the gene BECN1 and infarction.