Also, CHOP expression is elevated in several animal models of cerebral ischemia, including MCAo (Qi et al., 2004) and BCAo in mice (Tajiri et al., 2004; Osada et al., 2009), as well as MCAo and global ischemia in rats (Hayashi et al., 2005). The gene discussed is DDIT3; the disease is Cerebral ischemia.