Apoptosis resistance, overproduction of destructive proteinases (matrix metalloproteinases and aggrecanases), and inflammatory cytokines and chemokines (IL-1β, IL-6, IL-8, and TNF-α) have been well described in human primary RA synoviocytes and widely recognized as potential targets for arthritis therapy [20]. The gene discussed is CXCL8; the disease is Arthritis.