DICER1 and connective tissue disorder: Besides, according to the bioinformatic calculation using the Ingenuity pathway analysis (IPA) software (Figure 2(d)), the Dicer1 deficiency-induced dysregulated cytokines were predicted to be strongly implicated in several diseases and biofunctions including inflammatory responses, connective tissue disorders, inflammatory diseases, organismal injury and abnormalities, and skeletal and muscular disorders.