Migratory and invasive progressions are two major events in tumor metastasis.28 Over the past decade, EMT has been found to participate in metastasis by influencing cancer cell motility and dissemination.29 N‐cadherin and vimentin are generally used as mesenchymal markers for EMT.30 In addition, MMPs are positively related to tumor progression, metastasis, and prognosis of cancers.31, 32 Our study found that N‐cadherin, β‐catenin, vimentin, and MMPs were markedly upregulated in RCC cells overexpressing SELM. This evidence concerns the gene CDH2 and cancer.