Surprisingly, previous papers have demonstrated that CD44 negative (CD44‐) neuroblastoma cells are associated with all the phenotypic and molecular features required for neuroblastoma‐initiating cell growth.21, 22 However, in this study, we found that melatonin induced the expression of the hyaluronan synthase 3 (HAS3) protein. Here, HAS3 is linked to neuroblastoma.