According to a previous study, melatonin‐induced autophagy can be detected in differentiated glioma‐initiating cells.32 In this study, we suggest that HAS3 overexpression promotes the differentiation of N2a cells induced by physiological concentrations of melatonin (~10 nmol/L) and facilitates autophagy to eliminate neuroblastoma‐initiating cells in healthy individuals. Here, HAS3 is linked to glioma.