Recent studies showed that citalopram restores short‐term memory and treats depression‐like behavior in APPswe/PSEN1dE9 mice, preventing the advance of AD‐like pathology by increasing the number of neurons in the cortex with active parvalbumin (Zhang et al.2018), a calcium‐binding protein modulating synaptic activities (Caillard et al.2000). This evidence concerns the gene PVALB and major depressive disorder.