The ability of QE to induce apoptosis and autophagy by blocking STAT3 pathway has been clarified in different cancers, including ovarian cancer,8breast cancer,72glioblastoma18 and liver cancer.20It is also testified that the effect of QE is against the biological activity of migration and invasion by inhibiting STAT3.16, 18 At the same time, our results showed that QE could remit the changes brought by IL‐6.Thus, we confirmed that QE could reverse the changes caused by STAT3 activation (Figure 6). The gene discussed is STAT3; the disease is liver cancer.