STAT family has seven members, STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6,61 and STAT3 has been verified for its tumor promotor effect because activation of STAT3 could promote not only tumor cell proliferation and migration, but also angiogenesis and immunosuppression.21, 62, 63 There are some labs tesified the action of STAT3 in liver cancers,64, 65and the relationship among QE, STAT3 and HCC has been showed by several teams. The gene discussed is STAT5B; the disease is liver cancer.